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Thakur N*, Ray AP*, Sharp L, Jin B, Duong A, Pour NG, Obeng S, Wijesekara AV, Gao Z-G, Mccurdy CR, Jacobson KA, Lyman E, Eddy MT. Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature Communications (2023), 14. (* Authors contributed equally)

Ferré G, Anazia K, Silva LO, Thakur N, Ray AP, Eddy MT. Global insights into the fine tuning of human A2AAR conformational dynamics in a ternary complex with an engineered G protein viewed by NMR. Cell Reports (2022), 41, 111844.

Thakur N, Wei S, Ray AP, Lamichhane R, Eddy MT. Production of human A2AAR in lipid nanodiscs for (19)F-NMR and single-molecule fluorescence spectroscopy. STAR Protoc (2022), 3,101535.

Pritzlaff A, Ferré G, Mulry E, Lin L, Gopal Pour N, Savin DA, Harris ME, Eddy MT. Atomic‐Scale View of Protein‐PEG Interactions that Redirect the Thermal Unfolding Pathway of PEGylated Human Galectin‐3. Angewandte Chemie International Edition (2022), 61.

You X, Thakur N, Ray AP, Eddy MT, Baiz CR. A comparative study of interfacial environments in lipid nanodiscs and vesicles. Biophys Rep (N Y) (2022), 2.

Wei S, Thakur N, Ray AP, Jin B, Obeng S, McCurdy CR, McMahon LR, Gutierrez-de-Teran H, Eddy MT, Lamichhane R. Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered. Structure (2022), 30, 329-337.

Jacobson, Kenneth A., Zhan‐Guo Gao, Pierre Matricon, Matthew T. Eddy, and Jens Carlsson. Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines British Journal of Pharmacology (2022) 179, 3496-3511.

Eddy, Matthew T., Bryan T. Martin, and Kurt Wüthrich. A2A adenosine receptor partial agonism related to structural rearrangements in an activation microswitch Structure (2021) 29, 170-176.

Mulry E, Ray AP, Eddy MT. Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions. Biomolecules (2021) 11, 632.

Ferré, Guillaume, and Matthew T. Eddy. Structural biology of human GPCR drugs and endogenous ligands-insights from NMR spectroscopy Methods (2020) 180, 79-88.

Eddy MT, Yu Y-T, Wagner G, Griffin RG.  Structural Characterization of the Human Membrane Protein VDAC2 in Lipid Bilayers by MAS NMR Journal Biomolecular NMR (2019) 73, 451-460.










Shimada I, Ueda T, Kofuku Y, Eddy MT, Wüthrich K. GPCR Drug Discovery: Integrating Solution NMR Data with Crystal and Cryo-EM Structures Nature Reviews Drug Discovery (2019) 19, 59-82.



Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K. A2A adenosine receptor functional states characterized by 19F-NMR Proceedings of the National Academy of Sciences (2018) 115, 12733-12738.


Eddy MT, Gao Z-G, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K. Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor Journal of the American Chemical Society (2018) 140, 8228-8235.






Eddy MT, Lee M-Y, Gao Z-G, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K. Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor 

Cell (2018) 172, 68-80.


Press Release from The Scripps Research Institute

Press Release from SpectroscopyNow

Press Release from Genetic Engineering and Biotechnology News



White K*, Eddy MT*, Gao Z-G, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC. Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling Structure (2018) 26, 1-11. *Co-first authors

Cover of February edition of Structure: 


Eddy MT, Didenko T, Stevens RC, Wüthrich K. β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop Structure (2016) 24, 2190-2197.







Andreas LB, Reese M, Eddy MT, Gelev V, Ni QZ, Miller EA, Emsley L, Pintacuda G, Chou JJ, Griffin RG. Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers Journal of the American Chemical Society (2015) 137, 14877- 14886.

Eddy MT, Su Y, Silvers R, Andreas L, Clark L, Wagner G, Pintacuda G, Emsley L, Griffin RG. Lipid Bilayer- bound Conformation of an Integral Membrane Beta Barrel Protein by Multidimensional MAS NMR Journal of Biomolecular NMR (2015) 61, 1-12.


Eddy MT, Andreas L, Teijido O, Su Y, Clark L, Noskov G, Wagner G, Rostovtseva K, Griffin RG. Magic Angle Spinning Nuclear Magnetic Resonance Characterization of Voltage-Dependent Anion Channel Gating in Two- Dimensional Lipid Crystalline Bilayers Biochemistry (2015) 54, 994-1005.


Eddy MT, Yu T-Y. Membranes, Peptides, and Disease: Unraveling the Mechanisms of Viral Proteins with Solid State Nuclear Magnetic Resonance Spectroscopy Solid State NMR (2014) 61, 1-7.


Su Y, Sarell CJ, Eddy MT, Pashley C, Radford SE, Griffin RG. Secondary Structure in the Core of Amyloid Fibrils Formed from Human b2-Microglobulin and its Truncated Variant DN6 Journal of the American Chemical Society (2014) 136, 6313-6325.


Eddy MT, Belenky M, Sivertsen AC, Griffin RG, Herzfeld J. Selectively Dispersed Isotope Labeling for Protein Structure Determination by Magic Angle Spinning NMR Journal of Biomolecular NMR (2013) 57, 129-139.


Daviso, E, Eddy MT, Andreas LB, Griffin RG, Herzfeld J. Efficient Resonance Assignment of Proteins in MAS NMR by Simultaneous Intra- and Inter-residue 3D Correlation Spectroscopy Journal of Biomolecular NMR (2013) 55, 257-265.


Eddy MT, Ong T-C, Clark L, Teijido O, van der Wel PCA, Garces R, Wagner G, Rostovtseva TK, Griffin RG. Lipid Dynamics and Protein-Lipid Interactions in 2D Crystals Formed with the b-Barrel Integral Membrane Protein VDAC1 Journal of the American Chemical Society (2012) 134, 6375-6387.


Andreas LB, Eddy MT, Chou JJ, Griffin RG. MAS NMR of the Drug Resistant S31N M2 Proton Transporter from Influenza A Journal of the American Chemical Society (2012) 134, 7215-7218.


Eddy MT, Ruben D, Griffin RG, Herzfeld J. Deterministic Schedules for Robust and Reproducible Non-uniform Sampling in Multidimensional NMR Journal of Magnetic Resonance (2011) 214, 296-301.


Bayro MB, Debelouchina GT, Eddy MT, Birkett NB, MacPhee CE, Rosay M, Maas WE, Dobson CM, Griffin RG. Intermolecular Structure Determination of Amyloid Fibrils with Magic-Angle Spinning and Dynamic Nuclear Polarization NMR Journal of the American Chemical Society  (2011) 133, 13967-74.


De Paepe G, Lewandowski JR, Loquet A, Eddy MT, Megy S, Bockmann A, Griffin RG. Heteronuclear Proton Assisted Recoupling Journal of Chemical Physics (2011) 134, 095101.


Matsuki Y, Eddy MT, Griffin RG, Herzfeld J. Rapid Three-Dimensional MAS NMR Spectroscopy at Critical Sensitivity Angewandte Chemie (2010) 49, 9215-18.


Andreas LB, Eddy MT, Pielak RM, Chou JJ, Griffin RG. Magic Angle Spinning NMR Investigation of Influenze A M218-60: Support for an Allosteric Mechanism of Inhibition Journal of the American Chemical Society (2010) 132, 10958-10960.


van der Wel PCA, Eddy MT, Ramachandran R, Griffin RG. Targeted 13C-13C Distance Measurements in a Microcrystalline Protein via J-Decoupled Rotational Resonance Width Measurements ChemPhysChem (2009) 10,1656-63.


Lewandowski JR, De Paepe G, Eddy MT, Struppe J, Maas W, Griffin RG. Proton Assisted Recoupling at High Spinning Frequencies Journal of Physical Chemistry B (2009) 113, 9062-69.


Lewandoskwi JR, De Paepe G, Eddy MT, Griffin RG. 15N-15N Proton Assisted Recoupling in Magic Angle Spinning NMR Journal of the American Chemical Society (2009) 131, 5769-76.

Matsuki Y, Eddy MT, Herzfeld J. Spectroscopy by Integration of Frequency and Time Domain Information for Fast Acquisition of High-Resolution Dark Spectra Journal of the American Chemical Society (2009) 131, 4648-56.


Bayro MB, Ramachandran R, Caporini MA, Eddy MT, Griffin RG. Radio Frequency-Driven Recoupling at High Magic-angle Spinning Frequencies: Homonuclear Recoupling Sans Heteronuclear Decoupling Journal of Chemical Physics (2008) 128, 052321.


Mehta MA, Eddy MT, McNeill SA, Mills FD, Long JR. Determination of Peptide Backbone Torsion Angles Using Double-Quantum Dipolar Recoupling Solid-State NMR Spectroscopy Journal of the American Chemical Society (2008) 130, 2202-12.


Mehta MA, Fry EA, Eddy MT, Dedeo MT, Anagnost AE, Long JR. Structure of the Alanine Dipeptide in Condensed Phases Determined by 13C NMR Journal of Physical Chemistry B (2004) 108, 2777-80.

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